Sculptra® is a biostimulatory treatment designed to restore facial volume and brightness naturally — by stimulating your skin’s own collagen production. The result is gradual, graceful rejuvenation that enhances, rather than alters, your appearance. How Sculptra Works Unlike traditional fillers that add immediate volume, Sculptra works more subtly. The active ingredient, poly-L-lactic acid (PLLA), stimulates your body to rebuild collagen.